A mouse strain defective for alphabeta versus gammadelta T cell lineage commitment
نویسندگان
چکیده
منابع مشابه
Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment.
The mechanism of T cell precursor commitment to the gammadelta or alphabeta T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not possess the same discriminatory power. A counterbalance to the TCR as the lineage determinant is the pre-existing heterogeneity in gene expression ...
متن کاملT cell lineage commitment: identity and renunciation.
Precursors undertaking T cell development shed their access to other pathways in a sequential process that begins before entry into the thymus and continues through many cell cycles afterward. This process involves three levels of regulatory change, in which the cells' intrinsic transcriptional regulatory factors, expression of signaling receptors (e.g., Notch1), and expression of distinct homi...
متن کاملT cell lineage commitment: identity and renunciation1
Precursors undertaking T-cell development shed their access to other pathways in a sequential process that begins before entry into the thymus and continues through many cell cycles afterwards. This process involves three levels of regulatory change, in which the cells’ intrinsic transcriptional regulatory factors, expression of signaling receptors like Notch1, and expression of distinct homing...
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Years of controversy about the lineage relationship between alpha beta and gamma delta T cells may at last have been resolved: it now appears that most T cells derive from an identical T-lineage committed precursor.
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The T cell receptor (TCR)gammadelta and the pre-TCR promote survival and maturation of early thymocyte precursors. Whether these receptors also influence gammadelta versus alphabeta lineage determination is less clear. We show here that TCRgammadelta gene rearrangements are suppressed in TCRalphabeta transgenic mice when the TCRalphabeta is expressed early in T cell development. This situation ...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2002
ISSN: 1460-2377
DOI: 10.1093/intimm/dxf067